Left Ventricular Diastolic Dysfunction Frequently Occurs in Obstructive Sleep Apnea Patients

Obstructive sleep apnea has been related to increased cardiovascular risk. A recent research study examined the relationships between respiratory parameters and left ventricular abnormalities in obstructive sleep apnea.

One hundred and fifty newly diagnosed OSA patients without any known cardiovascular disease were included (age =49±11 years, BMI =27.1±3.3 kg·m^–2, respiratory disturbance index =41±18/h). Haemodynamic, biological, respiratory, cardiac and arterial parameters were assessed at inclusion.

Thirty-four patients (22.7%) had a grade 1 left ventricular diastolic dysfunction. Patients with an abnormal diastole were older (p<0.001) and 81% of them were hypertensive. The only respiratory parameter independently associated with the E/A ratio was mean nocturnal oxygen saturation. Seventeen patients (13%) had left ventricular hypertrophy.

A multivariate analysis showed that clinic systolic blood pressure and mean nocturnal oxygen saturation were independently associated with left ventricular hypertrophy. In a logistic regression model, an age 58 years (OR 3.29, 95% CI 1.78–5.64) and mean nocturnal oxygen saturation <92% (OR 2.76, 95% CI 1.45–4.91) were associated with left ventricular diastolic dysfunction.

Findings of this research study demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with obstructive sleep apnea and that it is related to the severity of oxygen desaturation.

Tagged with: Cardiovascular Risk • Diastole • Echocardiography • hypertension • Left Ventricular Hypertrophy • Obstructive Sleep Apnea • OSA • OSA Patients • Oxygen Desaturation • Respiratory Disturbance • Sleep Apnea • ventricular diastolic dysfunction

Filed under: Cardiovascular Disease • Obstructive Sleep Apnea • Sleep Apnea • Sleep Apnea News • Sleep Apnea Research • Sleep Apnea Study

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