Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) following respiratory muscle involvement. The researchers hypothesised that a questionnaire based on clinical symptoms and signs of diaphragm weakness can be used to screen for SDB in such patients.  

Researchers developed a self-administered multiple choice questionnaire containing five questions (SiNQ-5), scoring 0–10 points. 125 patients were enroled, 32 with respiratory muscle weakness, 35 subjects with normal respiratory muscle strength, and 58 patients with obstructive sleep apnea (OSA). All subjects underwent full polysomnography.

NMD patients with involvement of the respiratory muscles scored 6.8(2.3) out of 10 points, significantly higher than both OSA patients (2.5(2.3)) and normal subjects (1.0(2.0), p<0.001). A score of five or more points in the SiNQ-5 had a sensitivity of 86.2%, specificity of 88.5%, positive predictive value of 69.4%, and a negative predictive value of 95.5% to identify NMD with combined SDB.

A short self-administered questionnaire, the SiNQ-5, based on clinical symptoms can reliably screen for SDB in patients with diaphragm weakness. However, comorbidities, such as heart failure, that have symptoms influenced by posture could alter diagnostic accuracy.

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Filed under: Clinical Research • Obstructive Sleep Apnea • Polysomnography • Sleep Apnea • Sleep Apnea News • Sleep Apnea Research

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